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KMID : 0361420160400030481
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Journal of Korean Academy of Rehabilitation Medicine
2016 Volume.40 No. 3 p.481 ~ p.488
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Prediction of Functional Outcome in Axonal Guillain-Barre Syndrome
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Sung Eun-Jung
Kim Dae-Yul
Chang Min-Cheol
Ko Eun-Jae
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Abstract
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Objective: To identify the factors that could predict the functional outcome in patients with the axonal type of Guillain-Barre syndrome (GBS).
Methods: Two hundred and two GBS patients admitted to our university hospital between 2003 and 2014 were reviewed retrospectively. We defined a good outcome as being "able to walk independently at 1 month after onset" and a poor outcome as being "unable to walk independently at 1 month after onset". We evaluated the factors that differed between the good and poor outcome groups.
Results: Twenty-four patients were classified into the acute motor axonal neuropathy type. There was a statistically significant difference between the good and poor outcome groups in terms of the GBS disability score at admission, and GBS disability score and Medical Research Council sum score at 1 month after admission. In an electrophysiologic analysis, the good outcome group showed greater amplitude of median, ulnar, deep peroneal, and posterior tibial nerve compound muscle action potentials (CMAP) and greater amplitude of median, ulnar, and superficial peroneal sensory nerve action potentials (SNAP) than the poor outcome group.
Conclusion: A lower GBS disability score at admission, high amplitude of median, ulnar, deep peroneal, and posterior tibial CMAPs, and high amplitude of median, ulnar, and superficial peroneal SNAPs were associated with being able to walk at 1 month in patients with axonal GBS.
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KEYWORD
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Guillain-Barre syndrome, Functional outcome, GBS disability score, MRC sum score, Acute motor axonal neuropathy
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